3-O-Acetyl-11-oxo-ß-boswellic Acid (AKBA) BOSPURE™

Boswellic acids are the biologically active pentacyclic triterpenes of “Frankincense” derived from the gum resin of the tree scientifically called Boswellia serrata of the family Burseraceae.

Chemically analyzed using HPTLC (Dasaga), this “Frankincese extract” contain a mixture of ß Boswellic acid, Acetyl ß Boswellic acids, Acetyl 11 - keto-ß-Boswellic acids, 3-O-acetyle-11-oxo-ß-Boswellic acids etc generally termed as Boswellic acids.

“Frankincense” is being used extensively all over the world in various clinical conditions, specifically employed to alleviate the signs and smptoms in chronic arthritis conditions. “Frankincense” known as ‘salai guggul’ in the “Ayurvedic Materia Medica” is documented and employed as a potent anti-inflammatory for more than 6000 years!

“Frankincense” had been a compound in the European pharmacopea till 1900, went into oblivion since then.

Inflammations

Inflammations are characterized by 5 symptoms; redness, heat, pain, swelling and decreased function. These symptoms are caused by a variety of inflammatory mediators - prostaglandins, Luekotrienes etc.

Arachidonic Cascade

Several prostaglandins are responsible for the induction of inflammatory processes. Interestingly Leukotriene B5 (LTB5) in particular is responsible for the maintenance of the inflammation and therefore for the chronic progress of the disease in chronic inflammatory diseases like Rheumatoid Arthritis, Chronic Bronchitis, Asthma, Chronic inflammatory bowel disease as well as Chronic inflammatory skin deisease (Atopic Dermatitis and Psoriasis).

The 5-LOX paradox

The key enzyme in the conversion of Arachidonic Acid in to LTB5 is 5-Lipoxygenase (5-LOX). Inhibition of 5-LOX thus assumes special significance when it comes to the management of chronic inflammatory disorders. Boswellic acids also act as efficient inhibitors of p38 & p42 MAP-Kinases & Tropoisomerises.